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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 doi: 10.15302/J-FASE- 2021390
It has previously been shown that tryptophan, the biosynthesis precursor of Peganum harmala alkaloids, and its derivatives have anti-TMV activity both in vitro and in vivo. Further exploration of this led to the identification of NK0238 as a highly effective agent for the prevention and control of diseases caused by plant viruses, but the existing routes are unsuitable for its large-scale synthesis. This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophan with triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylamine to give NK0238 at up to 94% yield and nearly 97% HPLC purity. In addition, the route was used for the preparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicity tests. NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field experiments. The toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms. The optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies, its excellent activity and safety make NK0238 a promising drug candidate for further development.
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG
《农业科学与工程前沿(英文)》 页码 110-119 doi: 10.15302/J-FASE-2021390
关键词: antiviral plant protectant antiviral in the greenhouse field evaluation L-trp-NCA synthesis optimization toxicity tests
Laboratory and field evaluation of asphalt pavement surface friction resistance
Zhong WU, Chris ABADIE
《结构与土木工程前沿(英文)》 2018年 第12卷 第3期 页码 372-381 doi: 10.1007/s11709-017-0463-1
Pavement surface friction is a significant factor for driving safety and plays a critical role in reducing wet-pavement crashes. However, the current asphalt mixture design procedure does not directly consider friction as a requirement. The objective of this study was to develop a surface friction prediction model that can be used during a wearing course mixture design. To achieve the objective, an experimental study was conducted on the frictional characteristics of typical wearing course mixtures in Louisiana. Twelve wearing course mixtures including dense-graded and open-graded mixes with different combinations of aggregate sources were evaluated in laboratory using an accelerated polishing and testing procedure considering both micro- and macro texture properties. In addition, the surface frictional properties of asphalt mixtures were measured on twenty-two selected asphalt pavement sections using different in situ devices including Dynamic Friction Tester (DFT), Circular Texture Meter (CTM), and Lock-Wheel Skid Trailer (LWST). The results have led to develop a procedure for predicting pavement end-of-life skid resistance based on the aggregate blend polish stone value, gradation parameters, and traffic, which is suited in checking whether the selected aggregates in a wearing course mix design would meet field friction requirements under a certain design traffic polishing.
关键词: friction skid resistance polishing PSV LWST micro-texture macro-texture
《结构与土木工程前沿(英文)》 页码 1047-1059 doi: 10.1007/s11709-023-0034-6
关键词: warm permafrost expressway ventilation embankments temperature field
Giulia BONGIORNO
《农业科学与工程前沿(英文)》 2020年 第7卷 第3期 页码 257-274 doi: 10.15302/J-FASE-2020323
Developments in soil biology and in methods to characterize soil organic carbon can potentially deliver novel soil quality indicators that can help identify management practices able to sustain soil productivity and environmental resilience. This work aimed at synthesizing results regarding the suitability of a range of soil biological and biochemical properties as novel soil quality indicators for agricultural management. The soil properties, selected through a published literature review, comprised different labile organic carbon fractions [hydrophilic dissolved organic carbon, dissolved organic carbon, permanganate oxidizable carbon (POXC), hot water extractable carbon and particulate organic matter carbon], soil disease suppressiveness measured using a - bioassay, nematode communities characterized by amplicon sequencing and qPCR, and microbial community level physiological profiling measured with MicroResp . Prior studies tested the sensitivity of each of the novel indicators to tillage and organic matter addition in ten European long-term field experiments (LTEs) and assessed their relationships with pre-existing soil quality indicators of soil functioning. Here, the results of these previous studies are brought together and interpreted relative to each other and to the broader body of literature on soil quality assessment. Reduced tillage increased carbon availability, disease suppressiveness, nematode richness and diversity, the stability and maturity of the food web, and microbial activity and functional diversity. Organic matter addition played a weaker role in enhancing soil quality, possibly due to the range of composition of the organic matter inputs used in the LTEs. POXC was the indicator that discriminated best between soil management practices, followed by nematode indices based on functional characteristics. Structural equation modeling shows that POXC has a central role in nutrient retention/supply, carbon sequestration, biodiversity conservation, erosion control and disease regulation/suppression. The novel indicators proposed here have great potential to improve existing soil quality assessment schemes. Their feasibility of application is discussed and needs for future research are outlined.
关键词: labile carbon long-term field experiments organic matter addition soil biological indicators tillage
Recent progress in electric-field assisted combustion: a brief review
《能源前沿(英文)》 2022年 第16卷 第6期 页码 883-899 doi: 10.1007/s11708-021-0770-z
关键词: electric field combustion flame stabilization emission reduction flame propagation
A MATLAB code for the material-field series-expansion topology optimization method
《机械工程前沿(英文)》 2021年 第16卷 第3期 页码 607-622 doi: 10.1007/s11465-021-0637-3
关键词: MATLAB implementation topology optimization material-field series-expansion method bounded material field dimensionality reduction
Field test on temperature field and thermal stress for prestressed concrete box-girder bridge
Baoguo CHEN, Rui DING, Junjie ZHENG, Shibiao ZHANG
《结构与土木工程前沿(英文)》 2009年 第3卷 第2期 页码 158-164 doi: 10.1007/s11709-009-0002-9
关键词: box-girder bridge field test hydration heat temperature field temperature gradient thermal stress
《机械工程前沿(英文)》 2023年 第18卷 第2期 doi: 10.1007/s11465-022-0744-9
关键词: difficult-to-machine metal material green machining high-speed dry milling laser energy field-assisted milling ultrasonic energy field-assisted milling cryogenic minimum quantity lubrication energy field-assisted milling
Temperature field simulation of laser homogenizing equipment
Juanjuan WANG, Yunshan WANG, Fudong ZHU
《机械工程前沿(英文)》 2009年 第4卷 第1期 页码 49-52 doi: 10.1007/s11465-009-0005-1
关键词: laser homogenizing technology laser scanning ring facula temperature field
Sulige Gas Field super project
Wenrui HU, Jingwei BAO, Pengcheng JI
《工程管理前沿(英文)》 2017年 第4卷 第3期 页码 379-384 doi: 10.15302/J-FEM-2017107
A FEniCS implementation of the phase field method for quasi-static brittle fracture
HIRSHIKESH, Sundararajan NATARAJAN, Ratna Kumar ANNABATTULA
《结构与土木工程前沿(英文)》 2019年 第13卷 第2期 页码 380-396 doi: 10.1007/s11709-018-0471-9
关键词: phase field method FEniCS brittle fracture crack propagation variational theory of fracture
胡东生,张华京,庞西磊,徐冰,于学峰,田新红,安芷生,张国伟
《中国工程科学》 2008年 第10卷 第9期 页码 31-38
运用地球卫星观测手段及遥感信息提取技术及区域调查研究成果,首次对中国罗布泊核试验区进行全面分析及初步综合评价,揭示了鲜为人知的核爆炸效应及地质环境响应事件,对人类极端作用与重大工程环境及胁迫影响过程有了清晰实际的第一性材料,通过宏观清理和典型筛选对试验区自然环境要素变化进行逐项材料挖掘及客观评价,为国家安全利用核能与综合评估核环境及机动发展核战略提供科学基础数据。
Centrifuge model test and field measurement analysis for foundation pit with confined water
Chunlin DING , Xiaohong MENG ,
《结构与土木工程前沿(英文)》 2009年 第3卷 第3期 页码 299-304 doi: 10.1007/s11709-009-0035-0
关键词: foundation pit with confined water centrifuge model test seepage-stress coupling field similarity relation field measurement deformation
Study on the measurement of temperature field using laser holographic interferometry
Jinrong ZHU, Suyi HUANG, Wei LV, Huaichun ZHOU
《能源前沿(英文)》 2011年 第5卷 第1期 页码 120-124 doi: 10.1007/s11708-010-0107-9
关键词: temperature field flame error analysis holographic interferometry
标题 作者 时间 类型 操作
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
期刊论文
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
Wentao XU, Hao TIAN, Hongjian SONG, Yuxiu LIU, Yongqiang LI, Qingmin WANG
期刊论文
Laboratory and field evaluation of asphalt pavement surface friction resistance
Zhong WU, Chris ABADIE
期刊论文
Full-scale site evaluation of ventilation expressway embankments underlain by warm permafrost along the
期刊论文
Novel soil quality indicators for the evaluation of agricultural management practices: a biological perspective
Giulia BONGIORNO
期刊论文
Field test on temperature field and thermal stress for prestressed concrete box-girder bridge
Baoguo CHEN, Rui DING, Junjie ZHENG, Shibiao ZHANG
期刊论文
Energy field-assisted high-speed dry milling green machining technology for difficult-to-machine metal
期刊论文
Temperature field simulation of laser homogenizing equipment
Juanjuan WANG, Yunshan WANG, Fudong ZHU
期刊论文
A FEniCS implementation of the phase field method for quasi-static brittle fracture
HIRSHIKESH, Sundararajan NATARAJAN, Ratna Kumar ANNABATTULA
期刊论文
Centrifuge model test and field measurement analysis for foundation pit with confined water
Chunlin DING , Xiaohong MENG ,
期刊论文